Hi! Welcome to HCM! How are you? Brief answer: Side effects during the administration of drug: Chills, rigors, muscle ache, joint pains. etc Delayed side effects: Infections like pneumonia, reactivation of Tuberculosis, caner of lymph nodes, cancer of skin (melanoma) Detailed answer; Before commencing Simponi, you must rule out allergic reactions to it, Tuberculosis should be ruled out not only in the patients but also in house hold contacts. Using methotrexate together with Simponi may increase the risk of serious infections. Contact your doctor immediately if you develop fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Given along with Simponi Lamictol is less likely to cause any problem. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor. Best Regards!