Hello. Thank you for asking at HCM. I went through your wife s history. I would like to know more about her symptoms like - What are her symptoms while she consumes milk? Since what age she started having allergy reactions? What is the frequency of these reactions? Does she have any other medical problem? Does she take any regular/frequent drugs/medicines? Has she ever been investigated? Does she have fevers, joint pains, etc? From your given history, I would like to make following suggestions to your wife: 1. Were I treating her, I would suggest her Specific IgE by ImmunoCAP for milk protein or skin prick testing or preferably both for milk allergy. If it is positive, I would suggest her to restrict milk & milk products for at least 6 months. If it is negative, there are high chances she has milk intolerance rather than milk allergy, which is an entirely different condition. 2. Not all hives/swelling of body parts are always due to allergies, especially if they are present for more than several months and no clue can be thought of about precipitating factor. In such cases, I usually advise tests like complete blood counts, ESR, CRP, ANA, tests for liver, kidney & thyroid function, allergy testing, urine & stool examination, etc. Selection from these tests can only be done after reviewing complete history of the patient. I would also suggest her testing for physical urticaria which is performed by allergists/dermatologitsts. With these tests, usually diagnosis can be made in 60-70% of the cases, but not in all the cases. Hope above answer will be helpful to you. Should you have any other concern, please feel free to ask at HCM. Wish your wife the best of the health. Thank you & Regards.