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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Are The Symptoms And Treatment For Protein S Deficiency?

Hi Dr. Rynne. My 13 year old daughter is under the care of both her pediatrician and a gyno for dysfunctional uterine bleeding She is on day 134 of bleeding. The gyno completed a thrombophilia test last week and it just came back with a protein s deficiency. She does have a history of massive nosebleds as well. From all I have read, it seems that the deficiency should have the opposite effect on her. What is your take as we have now begun the wait to get in to see a pediatric hematologist? Thank you
Mon, 29 Dec 2014
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Pathologist and Microbiologist 's  Response
Hello and welcome to HCM,
Protein S is involved in coagulation pathway and thus deficiency of protein S will lead to bleeding disorders.
Your daughter is suffering from bleeding disorders- dysfunctional uterine bleeding and nose bleeds.
The deficiency of protein S is congenital in most of the cases and requires replacement with protein S.
Thus, you need to consult a hematologist for further work up.

Thanks and take care
Dr Shailja P Wahal
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What Are The Symptoms And Treatment For Protein S Deficiency?

Hello and welcome to HCM, Protein S is involved in coagulation pathway and thus deficiency of protein S will lead to bleeding disorders. Your daughter is suffering from bleeding disorders- dysfunctional uterine bleeding and nose bleeds. The deficiency of protein S is congenital in most of the cases and requires replacement with protein S. Thus, you need to consult a hematologist for further work up. Thanks and take care Dr Shailja P Wahal