Hi. Thanks for your query. Noted the history your wife suffering from Typhoid, changed two consultants but not working out. Taking Meflotas, Pantosec-D and Flexon. This indicates the following: - Meflotas Tablet is composed of the following active ingredients Mefloquine (250 mg) and works against Malaria, which you Doctor must have thought as a concurrent infection that can occur with Typhoid as Typhoid reduced the body resistance so much. - I am sure that your wife must have received antibiotic treatment active against Typhoid, which you have not mentioned. - Go for the blood, culture and sensitivity reports as this may find the proper infective agents and get a appropriate treatment to get a cure. - When there is no relief, better to go for further other tests like X-ray of the chest, ultrasonography of the abdomen and urine and stool tests as these can likely diagnose other concurrent infections. and get you proper treatment additionally.