What Can Be The Reason For Sudden Fluctuation In Creatine Level?

Dear sir, My husband is Type 1 diabetic for the past 15 years and nephorotic for the past 3 years, he is 36 years old now. He is supposed to take ACE inhibitors for the proteinuria. But his body is reactive to ACE inhibitors. So he is not taking any of the drug to stop the worsening of the kidney function. His cretinine value keeps fluctutuating between 1.0 and 2.6. But his ckp in elevated. cholestrol and BP is high. In this past 3years after becoming a nephrotis he had loads of probems. He had fistulla and that was removed. He had bone TB on the rib. Then a small bit of rib was removed. Now he was alright. Every month we have been checking his cretinine value, hemoglobin level and everything. Things are going well. But suddenly i observed a bulge on his right chest which looks like a fibroid, but not yet confirmed we haven t consulted the doctor which we will do in couple of days. So what can we do for this, will that dissolve by taking medicines or only through sugery. If that is possible through surgery can we go for laser? Without taking ACE inhibitors how long his kidney work or Is there any other medicines or any other way to stop worsening his kidney condition, Please suggest me............. Why his cpk is always high? We checked with the neurologist, we took relevant test, The doctor said that he does not have any neurological problems......Doctor says his decease does not follow the pattern of normal diabetic nephropathy because, his creatinine values goes suddenly up like 3 and with in two months setteled down to 1.2 like that...... Is it associated with any other decease....... kindly tell me? If you need any medical records of him I am ready to send kindly guide us please................