I qoke up with a clear to yellowish blister about 3/4 of an inch, oblong, on thr upper part of my right leg. I do get spider bites alit, but they are more of a painful red bump...no blisters. I have also had 2 operations for serious MRSA infections. I am 58, have Addison s disease and felt kind of yucky last few days, but usually vry active and happy.