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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Abnormal INR Levels Despite Taking Warfarin?

I AM BEING TESTED WEEKLY FOR INR. I AM TAKING WARFRAN FOR A BLOOD CLOT IN MY LUNG. HOWEVER, MY TESTS ARE ALL OVER THE PLACE. ONE WEEK I AM LOW NEXT WEEK I AM HIGH. MY DOCTOR KEEPS CHANGING DOSE OF WARFRAN. ANY HELP ON THIS ISSUE WOULD BE GREATLY WELCOMED. THANK YOU, JIM ALLIGER
Thu, 28 Dec 2017
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Pathologist and Microbiologist,  's  Response
Hello. Thanks for asking on Healthcaremagic. Titration of warfarin dose is very tricky. INR levels seem to fluctuate with mild modifications in diet and associated drug intakes. Also the warfarin tablet is supposed to be taken same time daily and sample given at a same time every time. Anything from 2-3 INR is good for anticoagulation. Lower will be ineffective and higher might cause bleeds. Sample should be given at a good laboratory and sampling errors can change INR. If needs to be transported then plasma needs to be separated and frozen immediately to be transported. All in all a delicate test. Thanks.
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What Causes Abnormal INR Levels Despite Taking Warfarin?

Hello. Thanks for asking on Healthcaremagic. Titration of warfarin dose is very tricky. INR levels seem to fluctuate with mild modifications in diet and associated drug intakes. Also the warfarin tablet is supposed to be taken same time daily and sample given at a same time every time. Anything from 2-3 INR is good for anticoagulation. Lower will be ineffective and higher might cause bleeds. Sample should be given at a good laboratory and sampling errors can change INR. If needs to be transported then plasma needs to be separated and frozen immediately to be transported. All in all a delicate test. Thanks.