Hello, since the drop in Globulin is not significant, to me it doesn t seems to be alarming. Having said this, its better to be safe than sorry so your doctor has rightly ordered electrophoresis as this will classify the globulins and will help in understanding which specific globulin is low (alpha1, alpha2, beta or gamma) Low Globulin Levels are indicative of some renal disease, hepatic dysfunction, celiac disease, inflammatory bowel disease (IBD), acute hemolytic anemia, agammaglobulinemia and hypogammaglobulinemia, autoimmune disorders. It could also mean protein metabolism defect in the digestive system (protien not being digested properly). Some medications like estrogen medications, steroids or drugs that are hepato-toxic can cause globulin levels to drop to a point which is unsafe. If you have recently started using a new medication, you will need to talk to your doctor about changing or eliminating your prescription. Hope your query is answered, for any further clarification, please fell free to revert. Thanks and take care.