Hi i am Dr Ahmed Aly thanks for using healthcaremagic site , I had gone through your question and understand your concerns .. Alot of causes for joint pain i think with your brother case ha have an underlying disease maybe autoimmine diseases like RA rheamatoid arithritis ,gout , SLE , bursitis ,lyme disease . for his urine problem he may have a culture and sensitivity test to diagnose the type of microorganism causing his urine infection for proper treatment if not i suggest a nephrologist . Please click THANK YOU and consider a 5 star rating with some positive feedback if the information was helpful. Hope the above information helps you, Any further clarifications feel free to ask.