Hi there, This sounds like interstitial cystitis, which is a condition in which the bladder is inflamed, and it feels like a urinary tract infection, but there actually is no infection. The symptoms you have (burning) and the fact that the urine culture is coming back normal means that you don t have an infection. Your doctor is correct that antibiotics aren t going to help. No one knows what causes Interstitial cystitis, but it is due to inflammation that isn t caused by infection, so likely an autoimmune problem. Thankfully, besides the discomfort, it doesn t cause any serious problems with long term consequences. I usually recommend my patients try ibuprofen, and this will often help with the inflammation in addition to the pain. If you don t have any kidney or stomach problems, then you can take about 800mg every 8 hours safely. I d try this for about 3-5 days and see if it helps. If you still continue to have problems, the next step would be to see a urologist and see what their recommendations are for treatment. I hope I have answered your questions. Please feel free to contact me if you have any further questions or if you feel I haven t addressed your question adequately.