THANK YOU AND PLEASED TO ANSWER YOU creatine phosphokinase elevations can be found without any health complaints. CPK elevated levels enzyme come from the muscles active work. muscles release CPK that tends to increase with heavy exercise. To make the things clear front of asymptomatic CPK increase, doctor check it again after 1 or 2 weeks exercise rest. Some drug has as side effects a rhabdomyolysis ( rhabdo and myo for rod-shaped muscle ; lysis for breakdown ) like statins. In obese patients, CPK value is not correlated to obesity checked by BODY MASS INDEX (BMI). Prednisone a corticosteroids drug, is not well for you as you are very obese and you might gain weight with it, and you are suffering from heart diseases, then you have to lose weight. Corticosteroids increase blood glucose, then you are asked to not use corticosteroids. Hypothyroidism often causes weakness, cramps, myalgia, and a mild to moderate serum CPK elevation. Serum CK levels are strongly affected by race, sex, and physical activity. A patient with truly elevated levels should be evaluated for a variety of nonneuromuscular causes, including endocrine disorders, metabolic disturbances, drug effects, and malignancy. If you are diagnosed Asymptomatic, no Treatment Exists and Course is Often Benign MAY THIS OPINION HELP YOU best wishes