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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Glucose-6-phosphate Dehydrogenase Deficiency?

good evening..im rina from philippines..my 1 mos and 14 days old daughter who is recently diagnosed of G6PD...and still waiting for confirmatory result..iam just wondering because her 1st NBS are all normal esp. the G6PD..and then her pedia advice to repeat again the NBS because my baby had an infection which is staphy species??(hospital acquired)and then her pedia gave her genta/ampi for 10 days..and after we test again her Culture and sensitivity test and its already NO GROWTH ..is it possible that my baby to get G6PD?because of the infection?even if her 1st NBS(before she took antibiotic)are all normal?hope you will answer my question for me to have comfort feeling....thank you...God bless!
Mon, 27 Nov 2017
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  Anonymous's Response
's  Response
G6PD Deficiency is an inherited condition, and so one cannot get it by infection or contact with someone who has G6PD Deficiency.

As the above condition is genetically inherited, these are the possibilities for how your daughter may have inherited it:

A) If the father is unaffected (healthy) and the mother is a carrier (no clinical symptoms):
One daughter out of two will be a carrier
One son out of two will be G6PD deficient

B) If the father is G6PD deficient and the mother is unaffected:
All daughters will be carriers
All sons will be unaffected

C) If the father is G6PD deficient and the mother is a carrier:
One daughter out of two will be G6PD deficient
One daughter out of two will be a carrier
One son out of two will be G6PD deficient
One son out of two will be unaffected

D) If the father is unaffected and the mother is G6PD deficient:
All daughters will be carriers
All sons will be G6PD deficient

E) If both father and mother are G6PD deficient:
All daughters will be G6PD deficient
All sons will be G6PD deficient


Also, with regards to the Newborn screening test being normal, the test may have been done too early or the blood sample taken was too small to diagnose the condition.


Note: For detailed guidance on genetic screening consult a genetics specialist
Disclaimer: These answers are for your information only and not intended to replace your relationship with your treating physician.
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What Causes Glucose-6-phosphate Dehydrogenase Deficiency?

G6PD Deficiency is an inherited condition, and so one cannot get it by infection or contact with someone who has G6PD Deficiency. As the above condition is genetically inherited, these are the possibilities for how your daughter may have inherited it: A) If the father is unaffected (healthy) and the mother is a carrier (no clinical symptoms): One daughter out of two will be a carrier One son out of two will be G6PD deficient B) If the father is G6PD deficient and the mother is unaffected: All daughters will be carriers All sons will be unaffected C) If the father is G6PD deficient and the mother is a carrier: One daughter out of two will be G6PD deficient One daughter out of two will be a carrier One son out of two will be G6PD deficient One son out of two will be unaffected D) If the father is unaffected and the mother is G6PD deficient: All daughters will be carriers All sons will be G6PD deficient E) If both father and mother are G6PD deficient: All daughters will be G6PD deficient All sons will be G6PD deficient Also, with regards to the Newborn screening test being normal, the test may have been done too early or the blood sample taken was too small to diagnose the condition.