My Dear Welcome to Healthcaremagic! I have analyzed your wife s details. SLE is an auto-immune disease which means that disease in which body mounts an attack against one of its normal components through the agency of immune system. Such diseases tend to behave unpredictably with more than one organ or type of tissue being affected simultaneously or in turns. I have every reason to conclude, based upon my experience with considerable number of not only SLE, but other auto immune diseases as well, that hair fall is quite common an occurrence with any of those conditions. However, the future is full of hope and there is a lot that you can ask her to do to get relief. 1 massaging should be gentle 2 no harsh shampoos 3 only dry hairs to be combed or preferably brushed as wet hairs are likelier to fall off easily 4 balanced diet and avoidance of hair chemicals and parlor procedures. I would prefer to give Biotin tablets to such patients as that helps most of them. Hopefully you will revert to use with positive news. Best wishes