Hi, Thanks for asking. Based on your query, my opinion is as follows. 1. Yes, serum ferritin is increased very much. 2. Increased iron levels usually indicate chronic anemias and hemosiderosis 3. As there are no possible infections, hemosiderosis needs to be considered. Evaluation for hyperpigmentation of skin, hepatomegaly and diabetes mellitus is necessary. 4. Liver biopsy can be helpful to look for tissue iron and also HFE gene evaluation can confirm the diagnosis. Do get the tests done at the earliest as multiple organ involvement can be serious and critical. Hope it helps. Any further queries, happy to help again.