My husband has been having joint pain. Knees, ankles, wrists, shoulders, accompanied with swelling. He is currently seeing a doctor, who has been prescribing Prednisone for more than a year. As soon as he quits taking the Prednisone, his symptoms flare up again. When he was 16 he was diagnosed with Reiter s Syndrome. This doctor tells him his shoulder pain is not associated with any kind of arthritis, but is a rotator cuff issue. I do not think that is the issue. I am wondering if Glucosamine would alleviate some of the pain.