Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. Losartan potassium is an angiotensin II receptor blocker. Common side effects may include: cold or flu symptoms, dry cough, muscle cramps, stomach pain, diarrhea, headache, dizziness, tiredness and sleep problems (insomnia). Amlodipine belongs to a class of drugs known as calcium channel blockers. Side effects of amlodipine include:Swelling (edema), headache, fatigue, palpitations, dizziness, nausea, flushing, abdominal pain, sleepiness, male sexual disorder, muscle cramps and muscle weakness. Both the drugs are essential and needs to be taken for treatment of hypertension. Libido what you are experiencing could be due to side effect caused by Amlodepine. You can consult your doctor for adjustment of dose regarding this medication, in case it is bothering you much and unable to overcome it by psychological means. Hope I have answered your query. Let me know if I can assist you further.