Yes, I have been have pains in my lower abdomen and I ve been taking gas x several times a day. I have been constipated and when I do finally go it is short skinny bums or diarrhea. I take medseveryday, I am diabetic. I take metformin, Crestor, Effexor, losartan for blood pressure and fenofibrate with prescription D2. I also take multi vitamin, turmeric, glucosamine condroiton and biotin