My husband started Effexor 5 days ago, and that is when i noticed significant mood changes. Seem s extremely irritable and very low self esteem. He has struggled with these issues before, but seemed to have a handle on them over the past few months, when he started being treated with Suboxone. Our lives seemed to finally calm down, and he was doing well, but a little depressed. So he started the Effexor, and now he s way worse. Is this an initial side effect of starting this medication?