Hello, This is Dr. Papaqako answering your question. Thank you for posting your query to HCM. Muscle twitching is not one of the side effects of Augpen (amoxicillin-clavulonate), and medicine side effects usually go away the next few days after stopping the medicine. So, I don t think that it has any relation with muscle twitching. The common, less serious causes of muscle twitching include exercise, stress and anxiety, caffeine and other stimulants, nutritional deficiencies, smoking. ect... There are also less common and more serious causes of muscle twitching. These medical conditions and illnesses are often related to your nervous system. They may damage the nerves connected to your muscles, leading to twitching. Some of these conditions include muscular dystrophy; Lou Gehrig’s disease (a rare disease that causes your nerve cells to die); spinal muscular atrophy; any trauma to a nerve leading to a muscle; muscle wasting or weakness, ect.. While muscle twitching is typically not an emergency, it may be linked to some serious medical conditions. Make an appointment with your doctor if your twitching becomes a chronic or persistent issue. Hope this helps, Take care.