Hi, Yes, numbness and tingling sensation can be a side effect of bupropion. However, it s also possible that the symptoms could be related to the cessation of sertraline. Both medications affect levels of neurotransmitters in the brain, so stopping one medication and starting another can sometimes lead to withdrawal or discontinuation symptoms. It s important to talk to your doctor about any new symptoms you experience after starting a new medication, especially if they are concerning or interfere with your daily activities. They may be able to adjust your dosage or recommend a different medication to manage your symptoms. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician