Why do I have numbness and tingling in my hands and feet even though I am taking three different blood pressure medications? My blood pressure still climbs often in spite of medication. My blood pressure right now, 30 minutes after taking lisinopril and clonidine is 130 over 85, heart rate 77. I take metoproloI, 25 mg, 2x a day, lisinipril, 20 mg, 2x a day and as of yesterday, clonidine, 0.1 mg, 2x a day. I still don t know why I have high blood pressure after two hospitalizations, mri, scans, blood tests and heart monitor. I don t have heart disease according to the cardiologist. I don t smoke or drink or do drugs. I do have anxiety problems but mostly controlled with Lorazepam which I rarely take. Any suggestions as to what s going on with blood pressure and tingling extremities?