Yes! My mom is 67 years old history of hypothyroid x20 years in September 2014 she became hyperthyroid, change in medication she noticed a change in her handwriting 1 week later loss of right thumb 1 week later right wrist drop digits 2,3, 4 start to appear clawed hyper reflexes right upper extremity all the above changes seemed to happen quickly over 3 weeks thyroid meds are supposively balanced she has seen a neurologist, orthopedist & now wait to have an MRI of her brain MRI C-spine clear