Hello, I understand your concern for persistent rash in groin skin fold. There can be multiple possibilities of the persistent rash in groin skin fold but most commonly it is seen after a fungal infection. Iti is due to moist area of the thigh fold which causes more of fungal infection of the affected area. In my patients I suggest them to apply clotrimazole cream or Sertaconazole or Amorolfine . In case f the infection is high then I suggest my patients to take anti-fungal tablets according to medical advice. Don t try to scratch or rub the area as can lead to further aggravation of the problem. For itching I prefer to give an antihistamine such as cetrizine or levocetrizine or loratadine for two times a day for few days. I also suggest wearing cotton clothes and cotton undergarments to be changed two times a day. Do not wear any synthetic or tight garments. All the best.