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What Causes Reduction In Growth Rate And Semi-solid Stool In Infant?
1 yo daughter had older sister die from leukemia (high risk due to LiFraumeni). Child has fallen in growth chart to less than 15% in height and weight since 3 months. Constant watery/sandy stools-never solid stool. Now is seeing PT for low muscle tone and weak core/hips. She scoots on her bottom, doesn t crawl. Just learned to roll over back to front. Concerns of mine are in labs-Normal WBC 12.6 with 19%Segs, 71%Lymph, 5%Mono, 4%Eos, 1%Bands. 33.8 HCT, 11.4 HGB, 33.7 MCHC. Also 92 glucose, 4 BUN, 0.23 Creatinine, 146 Triglycerides, 4.2 albumin, 2.2 globulin, 1.9A:G, 1.11 Free T4. Obviously concerns abound. Doc now referring us to Neurology (not sure why-waiting on call from him). I assume we are focusing on muscle issues, but don t want to overlook GI issues and lose sight of the fact that we have a genuine concern about what we ve endured before. BTW-DD1 wasn t diagnosed with usual ALL symptoms. She went into ER for Hip pain that caused her to not be able to walk. It resolved in 2 days but returned in other hip a week later. 1 lab with a couple blasts (normal WBC, RBC, DIFF, etc), prompted doc to order a consult with hematology, dx 3 weeks later with high risk pre b-cell ALL. she died 1 year later after GvHD battle.
Fri, 21 Aug 2015
Dear friend,
First of all, accept my condolences on the loss of your first daughter.
Coming to your current question, nothing in her symptoms or investigations seems to point to ALL as of now. If your concern is with 71% lymphocytes, this can be normal in a year old infant. Her other cell counts and biochemistry tests are normal.
As to whether she could be having a musculo-skeletal disorder, I am not currently knowledgeable enough to comment on what it might be, but I would suggest that if they want to get this diagnosis out of contention, they should consider a MITOCHONDRIAL disorder. I say this because both your children with illnesses were/are daughters, and mitochondrial myopathies are all inherited down the maternal line only to daughters.
Do revert if the tests turn up anything.
Dr. Taher
First of all, accept my condolences on the loss of your first daughter.
Coming to your current question, nothing in her symptoms or investigations seems to point to ALL as of now. If your concern is with 71% lymphocytes, this can be normal in a year old infant. Her other cell counts and biochemistry tests are normal.
As to whether she could be having a musculo-skeletal disorder, I am not currently knowledgeable enough to comment on what it might be, but I would suggest that if they want to get this diagnosis out of contention, they should consider a MITOCHONDRIAL disorder. I say this because both your children with illnesses were/are daughters, and mitochondrial myopathies are all inherited down the maternal line only to daughters.
Do revert if the tests turn up anything.
Dr. Taher
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