Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice.
The pain in thumbs accompained by weakness might be related to the thumb joint or to the tendons and ligaments surrounding the joint problems.
The thumb joint is commonly overused and this often leads to
arthritis of the joint, or an inflammation of the tendons around the joint, that causes pain.
The pain might also be related to
carpal tunnel syndrome, that is a very common cause of sharp
stabbing pain in the base of the thumbs , weakness and numbness, and occurs when your
median nerve gets compressed at the wrist .
In my opinion you should consult a doctor for a physical examination, to put the right diagnosis.
Meanwhile you can use antinflammatory drug for pain and inflammation relief,
Naproxen 500 mg daily.
Hope I have answered your query. Let me know if I can assist you further.