My daughters started unexplained weight gain out of nowhere. She was always thin. She has gained 50 pounds. She is on thyroid meds but they now question whether she should have ever been on. Her numbers were in range but she had symptoms. I think she is estrogen dominant bc she has acne break outs, oily hair, weight gain, irregular periods, horribly heavy periods when they come, etc. Her progesterone is .5. I want to try natural progesterone cream but the forums state horrible side effects such as bloating, weight gain, depression, etc. Do the natural creams have these bad side effects?