Hello. Thank you for your question and welcome to HCM. I carefully read your query. With the information you provided, I would say that we are facing a problem with your stomach. The chest discomfort, as you describe it, is called pyrosis, and is the burning-like sensation in chest which is produced by the returning of the highly acid stomach fluid into the oesophagus. This situation can be produced even if Helicobacter pylori is negative (it is present only in 30% of American population). Hereby, I would recommend you to follow the measures stated below. First, you have to lie down at least 90 minutes after you have had your last meal (the average time that stomach takes to push its content to the small intestine). Second, I would recommend refraining from some food and beverages that produce more acid and, thereby, irritate the gastric inner lining (mucosa), such as: - coffee, tea (xanthyne products) - chocolate - smoking and alcohol - pickles, grilled and spicy food Third, I would recommend you to start on a course with a protein pump inhibitor (PPI) drug. For instance, omeprazole 20 mg x 2 tb/d for the first two weeks and 20mg x 1 tb/d for two other weeks. After all these measures are undertaken by you, your symptoms should subside. If they remain present, I would recommend you to perform a upper gastro-intestinal (GI) endoscopy. I hope I was helpful. Take care and feel free to ask again.