Hello I understand your concern. It sounds that you cannot tolerate biological therapy due to drug-induced hepatitis. You mention you have a lot of flare ups ( I will assume more than 5 or 6 times a year). With flare-ups this often it certainly affects your quality of life with time spent away from work, recuperation, feeling ill, being uable to care for your son, etc. This is a very personal decision, that you alone can make. A bowel resection is a big step to take, but it may return your quality of life. Once recovered from the operation, a bowel resection will likely decrease incidences of flare-ups and help you feel healthier. You should have an in-depth discussion with your physician so you are well-informed of the pros and cons and be able to make an informed decision. Best of luck