hello. Welcome to HCM.
It is important to keep the bowel motility normal for a healthy feeling. A constipated person is prone to have gastric discomfort and feeling of malaise off and on.
You have tried various medications, which you say have not helped. In such a case, it is advisable to take organic bulk forming supports, e.g psyllium husk in lukewarm milk daily or alternate day at night or kaolin preparations. In case these are unpalatable for you, you can try psyllium tablets also. For all practical purposes, even their long term use is harmless. You can gradually reduce once you benefit.
It would also be helpful to eat healthy eating habits, like salads, green leafy vegetables, choker mixed flour or semi-polished rice. Yoga might be helpful.
for pain in knees, you need to have orthopedic examination, depending on your age. If females, an assessment of calcium and vitamin D levels and further replacement might be helpful.
take care

I believe either your eating habits or stressful conditions are responsible for your constipation. Have rich fiberous diet with more salad and green vegetables and have your diet at the right time. Take only freshly prepared food avoid fast food and stale food. Have proper rest and lot of water. Isabgol is the first line then harar and then senna compounds give relief. For total cure your will have to be regular with your dincharya and diet.

Hi,
Thanks for posting query.
Follow the advices properly-
1.     Take more fibre containing food.
2.     Take plenty of water.
3.     Avoid fried and junk food.
4.     Do regular physical exercise
Consult with physician for further proper management.
Wish you a speedy recovery.
Regards,
Dr Sourav Ganguly