I have been using a very low dosage of prempro for a number of years. (don t have dosage with me but the lowest) I have been successful, taking it. I just reviewed the side affects, and I am beginning to have body aches (lower) groin area and also cramps on the side of each leg & ankles. It gets worse at night. The latest incident is numbness in my left foot (toes) and tingling in the buttock area. I did have L-4 problems with my back, however, not sure of the type of issues are related to the back. It seems to be a neurological issue. Your thoughts? I just turned 70, in good health and go to the gym regularly. I don t have a weigh problem.