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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Will Taking Effexor And Bupropion Will Inhibit The Seratonin?

I have a constant sound in my head except for when I m using my brain for some current activity. I saw something that said it may be due to inadequate serotonin in my system. I take Effexor and bupropion which are described as seratonin uptake inhibitors. What is medically correct. My Dr. is unaware of my problem. W ould you please advise me or at least tell me if the medication I am taking inhibits Serotonin production in my body .is that what uptake prohibitors do?
Wed, 19 Oct 2016
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Neurologist,  's  Response
Hello! Effexor and Bupropion are both antidepressants but they use different mechanism of actions. Both inhibit the reuptake of neurotrasmitters. Effexor(velafaxine) inhibits the reuptake of serotonin and norepinephrine, bupropion inhibits the reuptake of dopamine. The production of serotonin is not affected, but the reuptake inhibition increases the level of serotonin to be used by the receptors, so in easy words effexor increases serotonin action.
Anyway, i don't think the sound in your head be explained by high levels of serotonin. In my opinion you're on the right drugs, since this complaint can be a sign of anxiety or mood disorder.
I hope i have been of help.
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Will Taking Effexor And Bupropion Will Inhibit The Seratonin?

Hello! Effexor and Bupropion are both antidepressants but they use different mechanism of actions. Both inhibit the reuptake of neurotrasmitters. Effexor(velafaxine) inhibits the reuptake of serotonin and norepinephrine, bupropion inhibits the reuptake of dopamine. The production of serotonin is not affected, but the reuptake inhibition increases the level of serotonin to be used by the receptors, so in easy words effexor increases serotonin action. Anyway, i don t think the sound in your head be explained by high levels of serotonin. In my opinion you re on the right drugs, since this complaint can be a sign of anxiety or mood disorder. I hope i have been of help.