HealthCareMagic is now Ask A Doctor - 24x7 | https://www.askadoctor24x7.com

question-icon

Are There Any Histamine 2 Receptors That Can Be Used Against Histamine Cascade?

default
Posted on Thu, 12 May 2016
Question: Are there any OTC H1 blockers which can be used effectively episodically to blunt histamine cascade in those with allergies or mast cell disorders?
doctor
Answered by Dr. Michelle Gibson James (49 minutes later)
Brief Answer:
most antihistamines are h1 blockers

Detailed Answer:
Hi, thanks for using healthcare magic

There was histamine 1 (h 1 ) and histamine ( h2 ) receptors and medications that block both.

The histamine 2 receptors are most commonly in the stomach but in persons with very severe allergies or urticaria, who do not respond to the normal meds, these are added to completely block the action of histamine in the body. Eg pepcid, zantac (used in non responsive , severe cases)

H1 blockers are the normal antihistamines that are usually available over the counter.
Eg benadryl, allegra, claritine, .There are even meds used for nausea that block H1 receptors eg dimenhydrinate (dramamine)

In addition to these antihistamines medications such as ketotifen or montelukast can be used.
Ketotifen is an antihistamine and also a mast cell stabiliser (it stops the mast cell from releasing the chemicals that cause the allergic response)
This may be over the counter.

Montelukast is a leukotriene receptor antagonist. Leukotriene plays a role in the allergic response.

I hope this helps, feel free to ask any other questions
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
default
Follow up: Dr. Michelle Gibson James (4 hours later)
Thank you very kindly Dr. James! Two follow-up questions:

I. If one cannot get ahold of one's physician at a given time, and if OTC H1 blockers don't adequately control the histamine response from mast cell activation and/or allergies, is it usually safe for the average person to combine OTC H1 and H2 blockers such as you mention?

II. Are there any effective natural alternative treatments for histamine responses from mast cell activation and/or allergies, such as quercetin, local honey, stinging nettle, or the like?

doctor
Answered by Dr. Michelle Gibson James (1 hour later)
Brief Answer:
can be used safely together

Detailed Answer:
HI

Yes, the combination can be used safely

In terms of effective natural remedies, you can use those that you mentioned as well as butterbur extrtract.

Other options would be the nete pot to rinse out your sinuses if congested, the use of filters at home to reduce allergen exposure.

Please feel free to ask anything else
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Michelle Gibson James

General & Family Physician

Practicing since :2001

Answered : 16808 Questions

premium_optimized

The User accepted the expert's answer

Share on

Get personalised answers from verified doctor in minutes across 80+ specialties

159 Doctors Online

By proceeding, I accept the Terms and Conditions

HCM Blog Instant Access to Doctors
HCM Blog Questions Answered
HCM Blog Satisfaction
Are There Any Histamine 2 Receptors That Can Be Used Against Histamine Cascade?

Brief Answer: most antihistamines are h1 blockers Detailed Answer: Hi, thanks for using healthcare magic There was histamine 1 (h 1 ) and histamine ( h2 ) receptors and medications that block both. The histamine 2 receptors are most commonly in the stomach but in persons with very severe allergies or urticaria, who do not respond to the normal meds, these are added to completely block the action of histamine in the body. Eg pepcid, zantac (used in non responsive , severe cases) H1 blockers are the normal antihistamines that are usually available over the counter. Eg benadryl, allegra, claritine, .There are even meds used for nausea that block H1 receptors eg dimenhydrinate (dramamine) In addition to these antihistamines medications such as ketotifen or montelukast can be used. Ketotifen is an antihistamine and also a mast cell stabiliser (it stops the mast cell from releasing the chemicals that cause the allergic response) This may be over the counter. Montelukast is a leukotriene receptor antagonist. Leukotriene plays a role in the allergic response. I hope this helps, feel free to ask any other questions