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Can Diphenhydramine Be Taken For Restless Legs Syndrome?

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Posted on Mon, 17 Oct 2016
Question: Can dyphenhydromine treat RLS & can I take 100mg if 50mg has no effect?
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Answered by Dr. Dr. Erion Spaho (12 minutes later)
Brief Answer:
It may exacerbate RLS.

Detailed Answer:
Hello and thanks for using HCM.

I have read your question and understand your concerns.

Diphenhydramine may exacerbate RLS symptoms, so, its use should be avoided if you are diagnosed with restless legs syndrome.

Drugs used for this purpose include ropinirol (requip), Pramiprexole (mirapex) etc.

Get tested about iron deficiency.

Discuss with your Doctor about these issues.

Hope you found the answer helpful.

Let me know if I can assist you further.

Take care.
Above answer was peer-reviewed by : Dr. Raju A.T
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Answered by
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Dr. Dr. Erion Spaho

Neurologist, Surgical

Practicing since :2004

Answered : 4502 Questions

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Can Diphenhydramine Be Taken For Restless Legs Syndrome?

Brief Answer: It may exacerbate RLS. Detailed Answer: Hello and thanks for using HCM. I have read your question and understand your concerns. Diphenhydramine may exacerbate RLS symptoms, so, its use should be avoided if you are diagnosed with restless legs syndrome. Drugs used for this purpose include ropinirol (requip), Pramiprexole (mirapex) etc. Get tested about iron deficiency. Discuss with your Doctor about these issues. Hope you found the answer helpful. Let me know if I can assist you further. Take care.