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Can Fluoxetine HCL, Venlafaxine And Bupropion Be Taken Together?

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Posted on Fri, 13 May 2016
Question: CAN YOU TAKE FLUOXETINE HCL, VENAFAXINE HCL ER, AND BUPROPION HCL XL TOGETHER XXXX
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Answered by Dr. Panagiotis Zografakis (36 minutes later)
Brief Answer:
you'd rather not!

Detailed Answer:
Hello,

all three of them interact with each other. Bupropion usage with any of the others may increase the risk for seizures in a dose-dependent fashion. Concurrent use of venlafaxine and fluoxetine increases the risk of serotonin syndrome which is potentially fatal. So you'd rather not use these drugs together.

Kind Regards!
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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Panagiotis Zografakis

Internal Medicine Specialist

Practicing since :1999

Answered : 3818 Questions

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Can Fluoxetine HCL, Venlafaxine And Bupropion Be Taken Together?

Brief Answer: you'd rather not! Detailed Answer: Hello, all three of them interact with each other. Bupropion usage with any of the others may increase the risk for seizures in a dose-dependent fashion. Concurrent use of venlafaxine and fluoxetine increases the risk of serotonin syndrome which is potentially fatal. So you'd rather not use these drugs together. Kind Regards!