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Can Lyrica, Temazepam, Endone, Panadeine Forte And Ativan Be Taken Together?

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Posted on Tue, 29 Sep 2015
Question: My Doctor has prescribed lyrica75mg at night I have 1 temazepan every 2nd night
how ever I am on 2 Endone 5mg & Ativan 2.5mg every morning I also have panadiene forte 1×3per day, I am wanting to know what drug interactions lyrica will have as I'm concerned about already being on other medication I'm afraid of overdosing my body.
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Answered by Dr. Bonnie Berger-Durnbaugh (52 minutes later)
Brief Answer:
Here is some information about interactions between your meds.

Detailed Answer:
What you are taking is -

Temazepam and Ativan - these are both from the drug class benzodiazepine which are sedatives, muscle relaxants and anti anxiety meds and will have the same side effects as each other (sedation, possible difficulty concentrating)

Endone and Panadiene forte both are types of opiates. Endone is oxycodone, and Panadiene is codeine (with acetaminophen which is not a narcotic/opiate).

Lyrica (pregabalin) is not a benzodiazepine or opiate, and is not explicitly contraindicated but can interact with both types of medications to increase sedation, light headedness/dizziness, and confusion.

I am not sure why you are on 2 different benzodiazepines and 2 different forms of opiates. Sometimes doctors prescribe one and then add another later without really paying attention that there was a similar one prescribed before. Or your doctor may have a reason for this particular repetition. I guess I would encourage you to politely ask your doctor what his/her thinking is to prescribe 2 different benzodiazepines and 2 opiates.

So in answer to your question, Lyrica is not contraindicated with your other meds but may cause more sedation with them.

I hope this information helps. Please let me know if I can provide further information or clarification.


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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Bonnie Berger-Durnbaugh

General & Family Physician

Practicing since :1991

Answered : 3133 Questions

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Can Lyrica, Temazepam, Endone, Panadeine Forte And Ativan Be Taken Together?

Brief Answer: Here is some information about interactions between your meds. Detailed Answer: What you are taking is - Temazepam and Ativan - these are both from the drug class benzodiazepine which are sedatives, muscle relaxants and anti anxiety meds and will have the same side effects as each other (sedation, possible difficulty concentrating) Endone and Panadiene forte both are types of opiates. Endone is oxycodone, and Panadiene is codeine (with acetaminophen which is not a narcotic/opiate). Lyrica (pregabalin) is not a benzodiazepine or opiate, and is not explicitly contraindicated but can interact with both types of medications to increase sedation, light headedness/dizziness, and confusion. I am not sure why you are on 2 different benzodiazepines and 2 different forms of opiates. Sometimes doctors prescribe one and then add another later without really paying attention that there was a similar one prescribed before. Or your doctor may have a reason for this particular repetition. I guess I would encourage you to politely ask your doctor what his/her thinking is to prescribe 2 different benzodiazepines and 2 opiates. So in answer to your question, Lyrica is not contraindicated with your other meds but may cause more sedation with them. I hope this information helps. Please let me know if I can provide further information or clarification.