Can Hypothyroidism Cause Low SGOT And SGPT Levels?

Brief Answer: No Detailed Answer: Hypothyroidism has not been known to be associated with low SGOT/SGPT levels. On the contrary, sometimes these enzymes can be elevated in this condition. The reason for this is not exactly understood but one proposed theory is decreased 'clearance' or elimination of these enzymes because thyroid hormones regulate metabolic functions in the body and therefore enzyme activity is also affected. However, there are couple circumstances where SGOT/SGPT can be elevated in association with a hypothyroid state. 1 Untreated/under-treated ie inadequately replaced thyroid hormone doses can result in a significant degree of 'under-activity' of the thyroid. One of the consequences of this is weight gain and obesity. Excess body fat can accumulate generally and may have a tendency to build up in the liver as well. This can result in a condition called 'Fatty Liver' or 'NAFLD' (Non Alcoholic Fatty Liver Disease', assuming the individual is not drinking significant amounts of alcohol). This condition can cause SGOT/SGPT to rise. Sometimes it may progress to XXXXXXX (Non Alcoholic Steato Hepatitis) which is inflammation of the liver cells. This can also be associated with elevations of SGOT/SGPT 2 The gall bladder contracts sluggishly in hypothyroidism and can be distended. Sometimes, gall stones may co-exist and if they block the flow of bile then SGOT/SGPT will rise too in conjunction with other enzymes like GGT 3 Finally, if hypothyroidism is a consequence of over-treatment with anti-thyroid medication such as PTU (Propyl thio uracil) and Methimazole used for the treatment of hyperthyroidism (an over active thyroid), then liver problems are uncommon side effects of this class of medications. This will also manifest as elevation of SGOT and SGPT amongst other liver-related presentations. If liver failure ensues, then these enzymes will go down low and this is an ominous sign of failing liver function

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Brief Answer: No known association Detailed Answer: In the published thyroid literature there is no description of low SGOT/SGPT levels in association with hypothyroidism

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Brief Answer: Endocrine Detailed Answer: Aside from the above mentioned situation of a failing liver where the liver enzyme levels drop, I cannot think of anything in my area of expertise (Endocrinology) that is associated with low SGOT/SGPT blood levels.

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