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Can Intake Of Prolia Cause Anxiety?

Posted on Wed, 9 Nov 2016

Question: My mother is 88 with bad osteoporosis, partially caused by a parathyroid adenoma which she has had for many years. She is on Sensipar to prevent calcium levels going too high. She wasn't keen on having to sit up in bed for half an hour with the Fosamax so the doctor recommended a Prolia injection once each six months. She has had two so far but I am worried about the following: if she has the injection and there are side-effects, there is no 'going back' - it's in place for six months; jaw osteonecrosis and not being able to have dentistry work done; the possible link between it and anxiety - she has had serious anxiety over the years and just in the last two months it has become a lot better. I am wondering if the Prolia might have contributed to it. What are your views? Is there a monthly Fosamax she could take instead or a monthly Prolia in case we notice side effects? Thank you.

Answered by Dr. Geeta Sundar (3 hours later)

Brief Answer:
Hi, Prolia contains Denosumab that can cause problems

Detailed Answer:
Hi, Welcome to HCM,

Prolia contains Denosumab that can cause problems in jaws, teeth and gums as you correctly said. It can also cause fall in blood pressure, thigh bone fractures, severe infections, bone and muscle pains, high cholesterol, and severe allergies.

Anxiety, though, does not seem a side effect.

There are oral and nasal formulations of denosumab which may soon be available. They are in the research stage.

Incidentally, Reloxefene can also be used. You can discuss this with your doctor.

Yes, Fosamax or Alendronate is available as 70mg and 40 mg oral form for weekly use. You can also discuss this with your doctor.

Hope this has helped.
Regards

Above answer was peer-reviewed by : Dr. Veerisetty Shyamkumar

Follow up: Dr. Geeta Sundar (2 days later)

Dear Dr XXXXXXX

Thank you very much for your reply. I think in view of this we might go back to Fosamax. Or Reoxefene - does that have fewer side effects?

Can Fosamax be taken once a month instead of once a week? (she doesn't like sitting up in bed afterwards!).

Many thanks

Answered by Dr. Geeta Sundar (4 hours later)

Brief Answer:
Hi, there is no once a month Fosamax.

Detailed Answer:
Hi, there is no once a month Fosamax. And since you are saying your mother is mostly in bed, Raloxefene is also not for her. Yes stick to Fosamax once a week. All the best and regards

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Above answer was peer-reviewed by : Dr. Nagamani Ng