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Does PSM Toxin Cause Septic Shock In People With Weak Immune System?
Question: I have already asked you a question about CA MRSA - but i dont know why i couldn't continue discussion
So i start a new discussion
Yes but is there - literature about PSM toxin that it won't spread fast like septic shock in health people
As all doctors agree wit that there should be written that in literature, but I cant find that.
So i start a new discussion
Yes but is there - literature about PSM toxin that it won't spread fast like septic shock in health people
As all doctors agree wit that there should be written that in literature, but I cant find that.
Brief Answer:
Unfortunately I could not find such a statement; but we can join the dots
Detailed Answer:
Hello sir and welcome.
Thank you for writing to us.
I have gone through your query and would like you to know that I am here to help. I understand that you have been searching for certain statements, but I have also searched for this statement and there is nothing like this around yet.
I have an alternative, as you must have read in many documents about the PSM toxin causing severe infections and even causing death in individuals with poor immunity. The death in such patients can be averted and also avoided with a good and strong regimen of antibiotics.
Whereas, in septic shock death is usually expected before day 28 from the infection. In majority of cases, death takes place within the first week from sepsis.
So comparing these two facts side by side, we can figure out that sepsis/septic shock will spread faster than the PSM toxin itself in healthy people.
I too agree with all doctors, but unfortunately there is no directly mentioning statement out there, and even if it is, it seems to be very difficult to find as I took enough and more time to try and find it, but I could not find it. So we can try to join the dots here and come to the conclusion you are wishing to see or learn.
I hope you find my response helpful. Please feel free to write back to me for any further clarifications, I would be more than happy to help you.
Best wishes.
Unfortunately I could not find such a statement; but we can join the dots
Detailed Answer:
Hello sir and welcome.
Thank you for writing to us.
I have gone through your query and would like you to know that I am here to help. I understand that you have been searching for certain statements, but I have also searched for this statement and there is nothing like this around yet.
I have an alternative, as you must have read in many documents about the PSM toxin causing severe infections and even causing death in individuals with poor immunity. The death in such patients can be averted and also avoided with a good and strong regimen of antibiotics.
Whereas, in septic shock death is usually expected before day 28 from the infection. In majority of cases, death takes place within the first week from sepsis.
So comparing these two facts side by side, we can figure out that sepsis/septic shock will spread faster than the PSM toxin itself in healthy people.
I too agree with all doctors, but unfortunately there is no directly mentioning statement out there, and even if it is, it seems to be very difficult to find as I took enough and more time to try and find it, but I could not find it. So we can try to join the dots here and come to the conclusion you are wishing to see or learn.
I hope you find my response helpful. Please feel free to write back to me for any further clarifications, I would be more than happy to help you.
Best wishes.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
How do you mean this?
So comparing these two facts side by side, we can figure out that sepsis/septic shock will spread faster than the PSM toxin itself in healthy people.
As you said and all doctors said that septic shock develop for people who are with weak immune system, and those who consider be healthy but have some immune system defects.
So how do you mean develop septic shock in healthy people – these are people with immune system defects ??
And in previous your answers you also said.
2. "And those who considers to be absolutely healthy and develop serve invasive CA MRSA infection have some immune system defect"
Yes, a few individuals who appeared to be healthy previously and are infected with CA MRSA have some immune system defect. But if you discuss the medical history of such individuals, you will find a long and frequent list of infections. So you cannot consider these individuals healthy at any point.
Brief Answer:
Yes, try to compare the two instead of finding the direct statement
Detailed Answer:
Hi sir.
Yes, I meant we should compare the two fact instead of going for a directly quoted statement and compare these two facts side by side.
Septic shock can appear in healthy individuals who have been through poor environmental situations. Like one soldier who I had met in a government hospital, who was perfectly healthy before he went out to the border, and while he was abandoned with a minor injury for days, he returned to the hospital and died due to septic shock.
My point here is that you wanted proof to show that PSM toxin will not spread as fast as septic shock/sepsis, and you wanted a statement proving this. Well as there is no direct statement for this, then why don't you compare the time taken for an individual with septic shock to spread, and another with PSM toxin.
2. Yes, I still stand by this.
Best wishes.
Yes, try to compare the two instead of finding the direct statement
Detailed Answer:
Hi sir.
Yes, I meant we should compare the two fact instead of going for a directly quoted statement and compare these two facts side by side.
Septic shock can appear in healthy individuals who have been through poor environmental situations. Like one soldier who I had met in a government hospital, who was perfectly healthy before he went out to the border, and while he was abandoned with a minor injury for days, he returned to the hospital and died due to septic shock.
My point here is that you wanted proof to show that PSM toxin will not spread as fast as septic shock/sepsis, and you wanted a statement proving this. Well as there is no direct statement for this, then why don't you compare the time taken for an individual with septic shock to spread, and another with PSM toxin.
2. Yes, I still stand by this.
Best wishes.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
About your answer!
-
Septic shock can appear in healthy individuals who have been through poor environmental situations. Like one soldier who I had met in a government hospital, who was perfectly healthy before he went out to the border, and while he was abandoned with a minor injury for days, he returned to the hospital and died due to septic shock.
-
As he (soldier) develop septic shock – and was healthy, then as I understand he had immune system defect. That’s why he develop septic shock !?
Or he develop septic shock because he ignored early symptoms and didn’t treat them!?
Septic shock means that it will develop fast blood stream infection?
Or it is infection that develop step by step ?
Septic shock can appear in healthy individuals who have been through poor environmental situations
So these are healthy people with immune system defects?
And such kind of healthy people with immune system defects who can develop septic shock are the smallest part of people ?
Or again these are healthy people who ignore early symptoms don’t treat in time ad develop septic chock ?
As I m health with no previous infection history, I m not at risk of septic shot!
If I go and get treatment early as possible !
(infectologist explained me that)
who have been through poor environmental situations
And by poor environment situations you mean bad hygiene or something else
Brief Answer:
All queries answered sir, pls do not hesitate to write back to me :)
Detailed Answer:
Hi sir.
No, soldiers are put through extensive health check ups before being set out for battle, so this soldier had absolutely no health issue or immune defect. He developed sepsis/septic shock due to the delay in medical attention provided, as he was at battle when his condition started deteriorating. So he developed sepsis because his early symptoms could not be treated.
Yes, people with immune defects can also develop such a situation of sepsis; but in this case a previously healthy person who did not receive medical attention for his early symptoms developed sepsis and eventually died.
People with immune defects can more easily develop sepsis, than a healthy individual.
As you are healthy with no previous infection, you are not at a risk for sepsis sir. Yes, if you are treated early and appropriately.
Yes, by poor environmental conditions I mean poor hygiene, poor weather (colder weather causes lowered immunity), bad nutrition, poor food intake, etc.
I hope this helps and is explained in a clear manner sir. Please do not hesitate to write back to me sir, I am always here to help. :)
Best wishes.
All queries answered sir, pls do not hesitate to write back to me :)
Detailed Answer:
Hi sir.
No, soldiers are put through extensive health check ups before being set out for battle, so this soldier had absolutely no health issue or immune defect. He developed sepsis/septic shock due to the delay in medical attention provided, as he was at battle when his condition started deteriorating. So he developed sepsis because his early symptoms could not be treated.
Yes, people with immune defects can also develop such a situation of sepsis; but in this case a previously healthy person who did not receive medical attention for his early symptoms developed sepsis and eventually died.
People with immune defects can more easily develop sepsis, than a healthy individual.
As you are healthy with no previous infection, you are not at a risk for sepsis sir. Yes, if you are treated early and appropriately.
Yes, by poor environmental conditions I mean poor hygiene, poor weather (colder weather causes lowered immunity), bad nutrition, poor food intake, etc.
I hope this helps and is explained in a clear manner sir. Please do not hesitate to write back to me sir, I am always here to help. :)
Best wishes.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
As all doctors say that – CA MRSA rapid septic shock can develop in people with weak immunes system, or in healthy persons with immune system defects. Why it is rear said in literature.
Or it is said just in medicine literature, but I read popular science literature that is not for doctors.
Some CA-MRSA strains display enhanced virulence, spreading more rapidly and causing illness much more severe than traditional HA-MRSA infections, and they can affect vital organs and lead to widespread infection (sepsis), toxic shock syndrome, and necrotizing ("flesh-eating") pneumonia. This is thought to be due to toxins carried by CA-MRSA strains, such as PVL and PSM, though PVL was recently found not to be a factor in a study by the National Institute of Allergy and Infectious Diseases at the National Institutes of Health. It is not known why some healthy people develop CA-MRSA skin infections that are treatable while others infected with the same strain develop severe infections or die.
http://en.wikipedia.org/wiki/Methicillin-resistant_Staphylococcus_aureus
Brief Answer:
Medical literature only, not other literature
Detailed Answer:
Hello sir.
There are many medical articles and discussions that have not been published in international literature, but have been archived in various medical journals and forums. This is merely due to the fact that some research is considered premature, some literature just does not have enough number of subjects, some literature was not important enough to document, more subjects studies need to be performed, and so on.
Some things remain unclear to us primarily because of the difference between the immune systems of the various subjects used in the study. We cannot grade their immune systems and give them points or marks, to later compare which one was more immunocompromised and survived or died due to CA-MRSA, and which one was less immunocompromised. This is the main reason why most things on this aspect remain unclear.
Best wishes.
Medical literature only, not other literature
Detailed Answer:
Hello sir.
There are many medical articles and discussions that have not been published in international literature, but have been archived in various medical journals and forums. This is merely due to the fact that some research is considered premature, some literature just does not have enough number of subjects, some literature was not important enough to document, more subjects studies need to be performed, and so on.
Some things remain unclear to us primarily because of the difference between the immune systems of the various subjects used in the study. We cannot grade their immune systems and give them points or marks, to later compare which one was more immunocompromised and survived or died due to CA-MRSA, and which one was less immunocompromised. This is the main reason why most things on this aspect remain unclear.
Best wishes.
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Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
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