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Does Theraflu Interact With Mirtazapine?

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Posted on Wed, 25 Jan 2017
Twitter Wed, 25 Jan 2017 Answered on
Twitter Thu, 16 Feb 2017 Last reviewed on
Question : can I take Theraflu for a cold if I am taking mirtazapine
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Answered by Dr. Bonnie Berger-Durnbaugh (37 minutes later)
Brief Answer:
Ok to take but be aware of possibility for increased sedation

Detailed Answer:
Hello,

I looked up the ingredients of Theraflu (acetaminophen, diphenhydramine, phenylephrine) and cross drug checked it with mirtazapine for interactions.

The combination of the diphenhydramine (the active ingredient in Benadryl -an antihistamine) with mirtazapine, can increase the sedative effects of the diphenhydramine.

What this means is that you can expect some increased sedation (and possible mental fogginess); and you probably shouldn't drive or do other things that require an alert mind until you know how a dose or two of this combination affects you.

I hope this information helps. Please let me know if I can provide further information.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Bonnie Berger-Durnbaugh

General & Family Physician

Practicing since :1991

Answered : 3133 Questions

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Does Theraflu Interact With Mirtazapine?

Brief Answer: Ok to take but be aware of possibility for increased sedation Detailed Answer: Hello, I looked up the ingredients of Theraflu (acetaminophen, diphenhydramine, phenylephrine) and cross drug checked it with mirtazapine for interactions. The combination of the diphenhydramine (the active ingredient in Benadryl -an antihistamine) with mirtazapine, can increase the sedative effects of the diphenhydramine. What this means is that you can expect some increased sedation (and possible mental fogginess); and you probably shouldn't drive or do other things that require an alert mind until you know how a dose or two of this combination affects you. I hope this information helps. Please let me know if I can provide further information.