High Level Of SGOT, SGPT, Gamma GT, Methotrexate For Psoriatic Arthritis.Treatment ?

Posted on Wed, 23 May 2012

Question: I have a high level of SGOT (AST) of 81 and SGPT(ALT) of 100 and Gamma GT is 55. I take 4 pills of Methotrexate every week since a long time due to my psoriatic arthritis. Should I be concerned or is there a treatment for this. I also take statins of 20 mg , Plavix and a blood pressure pill.

Answered by Dr. Poorna Chandra K.S (5 hours later)

Hi,

Thanks for the query.

Elevated SGOT, SGPT signify liver inflammation (hepatitis0. There are various causes of hepatitis like infection, abnormal immunity, fat deposition, due to drugs and some storage disorders.

Psoriasis is a disease caused by abnormal immune response to skin and joints and methotrexate acts by impairing immunity.

I advice you to see a gastroenterologist to examine you and perform appropriate test to pinpoint the cause of hepatitis.

Hope I have answered your query. I will be available for follow ups should you have any additional concerns.

Regards

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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar