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How Can A Lump In The Breast Be Treated?

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Posted on Thu, 17 Aug 2017
Question: Hell-o,
I am a 65 year old male diabetic. I have a long history of health issues. Here is a summary of key events:
Date           Event
Jan-92           Back surgery
Jun-96           surgery to remove lump in left breast
Jan-97           sleep study reveled severe sleep apnea. Started on BiPap machine
Jul-97           first diagnosed with diabetes
Aug-97           surgery to remove lump in right breast
Nov-97           first surgery on throat for sleep apnea Dr XXXXXXX
Jan-98           Broke Lt shoulder - surgery to repair w/3 pins
Dec-99           second surgery for apnea. Front of throat reconstructed Dr XXXXXXX Discontinued BiPap
Sep-00           Heart rate was considered too high and started medication to control pulse rate.
Oct-01           Irregular and rapid heart beat (Afib) first detected at doctor's office. Dr Schroeder
Feb-02           stasis dermatitis caused ulcers to open on my legs.
Apr-02           Admitted to hospital with heart failure. I was "flushed" of excessive water and my heart was resynchronized
Apr-02           Cardiac catheterization Hospital with positive results. Back on BiPap.
May-04           Cellulites in right leg
Dec-04           Cellulites in right leg
Jul-10           Cellulites in right leg
Dec-10           Surgery to remove Squamous Tumor on Rt leg
Aug-12           Surgery to correct eye alignment Dr. M McCarthy (Toledo)
Nov-14           Ablation procedure at BVH to correct A-Flutter
Nov-15           Lump in Rt Breast Reaccurred
Jan-16           ER Visit with bulge on right abdominal wall
May-16           MRI pituitary gland Indication: Hyperprolactinemia Dr. DEPAOLO
Jul-16           Colonoscopy & Esophagogastroduodenoscopy Dr. EL-ZUBEIDI

My current concern and the reason I am writing is the most recent occurrence of a lump in my right breast and the MRI indication of Hyperprolactinemia. At the time, I was referred to an endocrinologist. He ordered blood test for hormones and found Prolactin very high and Testosterone low He then ordered the MRI. He told me the high Prolactin was caused from the Hyperprolactinemia and this caused the low Testosterone. He said drug treatment could lower the Prolactin and this would help the Testosterone level. He prescribed Cabergoline 2.5 mg twice a week. Over the next couple months, my Prolactin level dropped to below the normal range but had no effect on the T levels. He ran several other blood test and then prescribed testosterone 1 ml, intramuscular once every two weeks.
At this point, my endocrinologist moved out-of-state. I live in a rural area. The closest other endocrinologist is a 100 mile round trip for me. My family doctor is helping me as much as possible but really wants he to see a specialist. I have a lot anxiety about traveling and would very much like to avoid the 100 mile trip.
My question today is it possible to get the specialized support I need, in conjunction with my family doctor,
From your online service? If so, what do I need to do to proceed?

Thank you in advance for your support.
doctor
Answered by Dr. Mirjeta Guni (8 hours later)
Brief Answer:
About online medicine:

Detailed Answer:
Hello and thank you for asking!
I can understand your situation.
Regarding to your question, I would say; from an online service you can get suggestions for a certain pathology (info about a certain pathology, the outcome of a disease, the alternatives of treatment, the side effects of the therapy etc) .
You should know that we can not make diagnosis or follow up a pathology without seeing the patient.
So, in your case, we can give suggestions but not decide for the treatment or give prescriptions.
Will be a pleasure to answer your queries but not give prescriptions for the treatment.
Kind regards,
Dr.Mirjeta
Above answer was peer-reviewed by : Dr. Yogesh D
doctor
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Follow up: Dr. Mirjeta Guni (2 hours later)
What are your suggestions regarding follow-up treatment for Hyperprolactinemia and low Testosterone?
doctor
Answered by Dr. Mirjeta Guni (3 hours later)
Brief Answer:
About prolactin and testosterone treatment:

Detailed Answer:
Welcome back,

First your physician should find the cause of high prolactin (Is a pituitary adenoma secreting more prolactine? Is an underactive thyroid causing it? Or are you taking medications that cause high prolactine level?)

The treatment depends on the cause.
If the prolactin level is normalized, and testosterone persists low, than age related hypogonadism is considered and the treatment consists in testosterone shots or gel (if there are no cardiac or prostate pathologies).
Of course the level of testosterone should be taken into consideration (how low it is and has it caused symptoms of low testosterone).
Please provide the above information for a further suggestion.
Kind regards,
Dr.Mirjeta
Above answer was peer-reviewed by : Dr. Remy Koshy
doctor
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Follow up: Dr. Mirjeta Guni (6 hours later)
A microscopic tumor on my pituitary gland is the cause of high prolactin (22-26 ng/mL before treatment). After the tumor was discovered with the MRI (May of 2016), I was prescribed Cabergoline 2.5 mg twice a week. Over the next couple months, my Prolactin level dropped to below the normal range (.28-.30 ng/mL). Cabergoline dosage was adjusted to 2.5 mg once a week. Prolactin levels have increased slightly (.4-.6 ng/mL) still below normal range. More recently, Cabergoline dosage was adjusted to 2.5 mg once every two weeks.
After starting the Cabergoline, my T levels remained low (110 - 180 ng/dL). I suffered symptoms of low testosterone (low energy, depression, sex performance). I started testosterone (1 ml, intramuscular once every two weeks) in December last year. Six weeks later, T levels still low (148 ng/dL). Testosterone dosage increase to 1.5 ml every two weeks. In May this year, T level checked in normal range (463 ng/dL) but the free T was above range (17.1 ng/dL). Currently, Testosterone dosage adjusted to 1.25 ml every two weeks.
Please let me know if I’m on the right track or if more testing is required.

doctor
Answered by Dr. Mirjeta Guni (15 hours later)
Brief Answer:
Low testosterone treatment;

Detailed Answer:
Welcome back,
Now the situation is more clear,
As the low levels of testosterone are not corrected after achieving normal prolactin levels, it means that testostetone production is lowered.
I suppose the thyroid function is within the normal ranges.
To maintain constant testostetone levels, testosterone gel is suggested.
With shots there are oscillations but it costs less than testostetone gel.
Regarding to pituitary microadenoma, at your age it can be left untreated ( the chances of adenoma to increase are very low, and high prolactine is not the cause of low testosterone).
Hope i have been helpful.
Kind regards,
Dr.Mirjeta
Above answer was peer-reviewed by : Dr. Remy Koshy
doctor
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Follow up: Dr. Mirjeta Guni (9 hours later)
It seems that you may have over looked the original reason for the MRI and the detection of the pituitary microadenoma when you suggest that it go untreated. I had a lump growing in my right breast. After starting the Cabergoline and Prolactin levels dropping, the lump shrank and now is almost nonexistent. I am very concerned that unchecked Prolactin will cause breast lumps to reoccur. Is this concern justified? Also, I am concerned that my current condition of low Prolactin is not acceptable either. Do you believe the adjustment of Cabergoline dosage from 2.5 mg once every week to 2.5 mg once every 14 days will normalize Prolactin? What action do you suggest?

Testosterone gel is not covered by my drug plan so I am stuck with shots. My question here is what should I target as “normal”? Should I be more concerned with Total T or Free T? Are there other blood test that should be concered?
I look forward to your reponse.
doctor
Answered by Dr. Mirjeta Guni (16 hours later)
Brief Answer:
About testosterone monitoring therapy:

Detailed Answer:
Hi again,
Yes, your concern regarding to the breast lump is right.
Is i mentioned before, we suggest to treat prolactinomas (pitutitary micro adenomas) when high prolactin levels cause side effects (low testosterone , infertility in young ages, gynecomastia or breast lumps).
So, if the lump is shrinked after correction of the prolactin, it is recommended to continue with dostinex ( 2.5 every 2 weeks will e probably the right dose)
When using testosterone, we measure total blood testosterone levels right before the next corresponding injection after the first month (it takes a while for the blood levels to stabilize). If testosterone is >700 ng/dl (24.5 nmol/liter) or <350 ng/dl (12.3 nmol/liter), the adjustment of the amount or the frequency of your dose is recommended. While monitoring the dose of testosterone,except of testoterone levels, the clinical symptoms are very important. Some men need to have levels above 500 ng/dl to experience any of the expected sexual function benefits from testosterone.
You should monitor also Hematoctrit, PSA, Liver function tests, prostate volume 3-6 months after starting testosterone therapy.
Best wishes,
Dr.Mirjeta
Note: For more information on hormonal imbalance symptoms or unmanaged diabetes with other comorbid conditions, get back to us & Consult with an Endocrinologist. Click here to book an appointment.

Above answer was peer-reviewed by : Dr. Kampana
doctor
Answered by
Dr.
Dr. Mirjeta Guni

Endocrinologist

Practicing since :2006

Answered : 2413 Questions

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How Can A Lump In The Breast Be Treated?

Brief Answer: About online medicine: Detailed Answer: Hello and thank you for asking! I can understand your situation. Regarding to your question, I would say; from an online service you can get suggestions for a certain pathology (info about a certain pathology, the outcome of a disease, the alternatives of treatment, the side effects of the therapy etc) . You should know that we can not make diagnosis or follow up a pathology without seeing the patient. So, in your case, we can give suggestions but not decide for the treatment or give prescriptions. Will be a pleasure to answer your queries but not give prescriptions for the treatment. Kind regards, Dr.Mirjeta