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How Long Does Amitriptyline Tablet Take To Get Out Of The System?

Posted on Mon, 25 May 2015

Question: I took 1/4 of a 10mg amitriptyline tablet once at night for 4 nights. How long will it take for the amitriptyline to get out of my system?

Answered by Dr. Panagiotis Zografakis (7 minutes later)

Brief Answer:
May take from 2 to 5 days

Detailed Answer:
Hello,

for complete removal of the drug from your body, it will take from 2 to 5 days. This drug has a half-life of 9-27 hours depending on various unpredictable (for any particular individual) factors. Complete removal (more than 95% of the drug) requires 5 half lives that is 45 to 135 hours (2-5 days).

I hope I've helped!
Kind Regards!

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Panagiotis Zografakis (6 minutes later)

2.5 mg of amitriptyline is a rather small dose, correct? I am also taking 1/2 of a .25mg xanax pill during the morning hours. I am going to a social event this evening and was told by my pharmacist that it should be safe to drink a glass of wine...but I forgot to mention the amitriptyline I had taken until Friday. Should it still be ok for me to have a single drink at this social event. I know to be aware of drowsiness and possible enhanced effects due to the xanax, my concern is with the possible residual amitriptyline also in my system. Thanks again.

Answered by Dr. Panagiotis Zografakis (8 minutes later)

Brief Answer:
You're probably safe!

Detailed Answer:
Hi,

2,5mg is a very very low dose and two days after taking it a large part of it has already been metabolized. So although amitriptyline may potentiate the effects of alcohol, I do not consider this a high risk.

Kind Regards!

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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar