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How Long Does Divalproex Sodium Take To Clear Out Of Body?

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Posted on Thu, 7 Jul 2016
Question: Hi,

I have bipolar disorder.
Taking Divalproex Sodium from last 10 Years.
1500 mg per day.
Now doctor says no need to continue medicine.
Has tapered to 250 mg and now discontinued
How long will it take to clear the system .

Thanks.
doctor
Answered by Dr. Chintan Solanki (20 minutes later)
Brief Answer:
3-4 days maximum after last dose

Detailed Answer:
Hello XXXX,

Thanks for writing to us.

In patients with bipolar disorder medicines can be stopped if there is no episode of depression or mania for significant period (which depends on overall history of bipolar).

Maximum half-life of divalproex sodium is 16 hours. In general drug takes 5 half-lives to clear from the body. So drugs will clear from the system in approximately 80 hours (3-4 days).

Hope I have answered your query, I will be happy to help further.
Regards,
Dr.Chintan Solanki.
Note: For further guidance on mental health, Click here.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Chintan Solanki

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Practicing since :2007

Answered : 2406 Questions

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How Long Does Divalproex Sodium Take To Clear Out Of Body?

Brief Answer: 3-4 days maximum after last dose Detailed Answer: Hello XXXX, Thanks for writing to us. In patients with bipolar disorder medicines can be stopped if there is no episode of depression or mania for significant period (which depends on overall history of bipolar). Maximum half-life of divalproex sodium is 16 hours. In general drug takes 5 half-lives to clear from the body. So drugs will clear from the system in approximately 80 hours (3-4 days). Hope I have answered your query, I will be happy to help further. Regards, Dr.Chintan Solanki.