Is KRAS Mutation Colon Cancer Resistant To Chemotherapeutic Protocols?

Posted on Tue, 28 Apr 2015

Medically reviewed by Ask A Doctor - 24x7 Medical Review Team

Tue, 28 Apr 2015 Answered on

Fri, 15 May 2015 Last reviewed on

Question : Is KRAS mutant colon csncer stage 4 usually resistant to chemotherapy ?

Answered by Dr. Dr. Ivan Romich (1 hour later)

Brief Answer:
In KRAS poz cancer there is poor chemoth effect

Detailed Answer:
Hi and welcome.
Generally yes. Cancers positive to KRAS mutation are more resistant to almost all chemotherapeutic protocols, but some smaller part of such patient may still show some benefit of chemotherapy especially oxaliplatin based medications. However, in stage 4 with distant meastases and inooeprable liver lesions, there is generaly poor prognosis but it is worth to try with palliative measures. WIsh you good health. Regards

Above answer was peer-reviewed by : Dr. Raju A.T