Brief Answer:
NO CONCLUSIVE STUDIES, DO NOT WORRY IF USED.

Detailed Answer:
Hello
Thanks for writing to us.
Duphaston contains Dyhydrogesterone, which is a type of progesterone preparation, containing a hormone that supports the growing pregnancy.
It is indicated and generally given to patients with a history of previous abortions and miscarriages, and with a risk of miscarriage in the current pregnancy.
Countries like the USA, Canada, Australia and even UK do not approve the use of Duphaston during pregnancy for this indication, however it is routinely prescribed in India during the first trimester of pregnancy.
There are no conclusive studies which prove that Duphaston causes any harm to the unborn baby if consumed during pregnancy.
This subject is still a grey area of research, however, as it is not supported by major countries, I would not recommend it to a patient.
There are safer alternatives containing progesterone, which can be given for the same purpose.
However, if you have already taken Duphaston, do not worry, as I said earlier, there are no proved side effects on the fetus.
Take care, and feel free to discuss further.

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Brief Answer:
DETAILED BELOW

Detailed Answer:
Hi,

I have not received any attachment.

Please send it , as I would like to go through it.

As I said, I would not recommend it to a patient, as it has plausible ( possible ) association with certain defects in the baby, including cleft palate.

However, there is no CONCLUSIVE study that convincingly says that this is the case.
Also, no baby dies of only cleft palate.

There have to be associated anomalies which are life threatening.

There could be various other causes such as chromosomal disorders ( syndromes ), intake of teratogenic drugs, deficiency of folic acid, smoking etc.
Please consult a Fetal Medicine expert to know the exact cause.
Diabetes, hypothyroidism in the mother should be ruled out.

The fetus should have been sent for detailed examination and biopsy.
5- MHTF is the active metabolite of folic acid.

You can take Iberet 500, however ideally 5 mg of folic acid per day is recommended in women who have had a child with previous birth defects.
Take care.

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Brief Answer:
DETAILED BELOW

Detailed Answer:
Hello
The recurrence rate of single umbilical artery is less than 1 %, unless it is part of a known chromosomal disorder.
So you have excellent chances of having a normal baby the next time.
I hope your fetus was sent for detailed chromosomal analysis.
Duphaston is reported to have associations with anomalies, but there is NO direct scientific study regarding the same.
You should wait for atleast 6 months before planning your next pregnancy and take 5 - MHTF or equivalent of 5 mg. folic acid per day ( Folvite is a suggested brand ), before planning your next pregnancy.
All the best.

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Brief Answer:
DETAILED BELOW

Detailed Answer:
Hi,

It is always better to send the fetus for detailed testing.
However, do not stress out.

And do not let this event disturb your mind and body.
Take the medication as advised, and plan for pregnancy after 6 months.
All the best.

Please feel free to discuss with me anytime.

I wish you lots of luck and happiness.

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Brief Answer:
TESTS AS SUGGESTED

Detailed Answer:
You can take folic acid 5 mg per day.

Apart from that, I recommend my patients with similar presentation to test for
1. Diabetes
2. Hypothyroidism
3. Hypertension
4. Screening for rubella, cytomegalovirus, herpes, toxoplasmosis
5. Blood grouping of husband and wife, and viral markers - HIV, hepatitis B, hepatitis C
6. Fetal autopsy if possible
7. Screening for antiphospholipid antibodies

Your doctors will know about these tests.

Regards

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Brief Answer:
-

Detailed Answer:
All the best dear.
Take care.

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