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Is Taking Pristiq 50mg And Trazodone 25mg At Night For Sleep Safe?

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Posted on Tue, 6 Sep 2016
Question: Is taking Pristiq 50mg and trazodone 25mg at night for sleep safe?
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Answered by Dr. Olsi Taka (14 minutes later)
Brief Answer:
Not safe.

Detailed Answer:
I read your question carefully and I understand your concern regarding drug interactions.

I am afraid that combination is not safe. Those are two antidepressants which both increase the levels of a neurotransmitter called serotonin and as a result cause what is called serotonin syndrome.

It is very rare but can be life threatening so for that reason their use together is not recommended and some other alternative must be used.

I remain at your disposal for further questions.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Olsi Taka

Neurologist

Practicing since :2004

Answered : 3673 Questions

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Is Taking Pristiq 50mg And Trazodone 25mg At Night For Sleep Safe?

Brief Answer: Not safe. Detailed Answer: I read your question carefully and I understand your concern regarding drug interactions. I am afraid that combination is not safe. Those are two antidepressants which both increase the levels of a neurotransmitter called serotonin and as a result cause what is called serotonin syndrome. It is very rare but can be life threatening so for that reason their use together is not recommended and some other alternative must be used. I remain at your disposal for further questions.