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Is There Interaction Between Promethazine And Tramadol?

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Posted on Mon, 27 Jun 2016
Question: can I take two 25 mg of promethzine after taking 1 and half tramadol 5 hours ago have terrible migrane with nausea.
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Answered by Dr. Bonnie Berger-Durnbaugh (1 hour later)
Brief Answer:
Promethazine and Tramadol

Detailed Answer:
Hello and welcome,

If the Tramadol you have is immediate release (not extended release) and if it is not a repeat dose (i.e. you only took 1 dose today), then after 6 hours, it would be safe to take the promethazine. The combination of the two has the potential to increase the risk for seizures.

I hope this information helps. Please let me know if I can provide further information or clarification.
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Bonnie Berger-Durnbaugh

General & Family Physician

Practicing since :1991

Answered : 3133 Questions

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Is There Interaction Between Promethazine And Tramadol?

Brief Answer: Promethazine and Tramadol Detailed Answer: Hello and welcome, If the Tramadol you have is immediate release (not extended release) and if it is not a repeat dose (i.e. you only took 1 dose today), then after 6 hours, it would be safe to take the promethazine. The combination of the two has the potential to increase the risk for seizures. I hope this information helps. Please let me know if I can provide further information or clarification.