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Suggest Dosage For Evion

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Posted on Tue, 10 Nov 2015
Question: Your question: "Sir my hubby was dignosed with fatty liver on XXXXXXX 16 this year.his sgpt was 186 and sgot was 140.never drink or smoke.his ldl cholesterol levels were elevated.he doesn't have diabetes for sure.he started taking evion 400 daily and exercise and diet control also.his sgot got normal yes.his sgpt dropped to 66 but den he stopped taking evion and within 2 months sgpt increased to 91. sir does he need to take evion for life??he was taking 400 units bd.if if he stop taking evion after some months or years den will his sgpt levels increase again despite proper exercise and diet control? ?his wt is 74kg and ht is 5'11".thanks in advance sir.
doctor
Answered by Dr. Dr.P.Ratnakar Kini (1 hour later)
Brief Answer:
Treat high cholesterol.

Detailed Answer:
Hi,
Thanks for posting your query.
I am Dr.R.K and I am pleased to assist you.

Your husband is having non alcoholic fatty liver disease.
Some of the common causes of NAFLD are obesity, diabetes, high cholesterol etc.

Your husband's BMI is 22.7. So he is not obese. ( Obesity/overweight - BMI more than 25). He is also not a diabetic.
The risk factor is high cholesterol . He needs to take medications to bring it under control. Only then his fatty liver will become normal. You can get a prescription from his doctor.
Evion is just a supportive medication. He need not take it lifelong.
He will get more benefitted if he takes Trimeg.

I hope that answers your question.
Let me know if you have any more questions.
Regards,
Dr.R.K
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Dr.P.Ratnakar Kini (4 minutes later)
Hello sir now his ldl cholesterol and triglycerides have come to normal after taking atorvastatin.sorry i forgot to mention that.but still his sgpt was 91.
Can sgpt be elevated despite normal cholesterol levels also??his hdl cholesterol is 40.
Sir do you think fibrosis has set in and that's why sgpt is elevated??
and sir is it it definitely XXXXXXX or simple fatty liver.
doctor
Answered by Dr. Dr.P.Ratnakar Kini (11 minutes later)
Brief Answer:
Other causes of raised liver enzymes should be ruled out.

Detailed Answer:
Hi,
Within 3-6 months of eliminating the risk factors, the fatty liver will become normal.

I presume an ultrasound scan was done to diagnose fatty liver. Simple fatty liver will have normal liver enzymes. Since he is having raised enzymes he is having steatohepatitis. Whether it is nonalcoholic steatohepatitis (NASH) or steatohepatitis due to other causes can be known only with more tests.

He should be tested for other causes like Hepatitis B and C infections, autoimmune diseases, metabolic diseases of liver.
You can consult a gastroenterologist/hepatologist for these tests.

To know whether fibrosis has set in a fibroscan may be done.

I hope that answers your question.
Let me know if you have any more questions.
Regards,
Dr.R.K




Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Dr.P.Ratnakar Kini (6 minutes later)
Sir his hepatitis tests were normal and asma ana ttg were also normal.then sir what could be reason for elevated sgpt??can you suggest other metabolic tests??ceruloplasmin also normal.yes.
sir do you think any other serious reason behind this??bilirubin was also normal sir.i am under lots of stress sir.pls tell can he have a normal lifespan despite all these problems??
doctor
Answered by Dr. Dr.P.Ratnakar Kini (4 minutes later)
Brief Answer:
Please upload all the tests reports here

Detailed Answer:
Hi,
Please upload all the test reports here.
Regards,
Dr.R.K.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Dr.P.Ratnakar Kini (16 minutes later)
Date 16th june-sgpt 187 sgot 140.
s.amylase-88.
lipase-215.
bulirubin tot-0.7
direct 0.1 indirect 0.60
t3 tsh t4 all normal.
ldl-134.
vldl-42
ldl/hdl-4.47
triglycerides -209
total cholesterol -206.

Date2nd july-sgpt 96 sgot 53.
bulirubin normal.
cholesterol all normal.
ESR AFTER 1 HOUR-06.
ESR AFTER 2 HOUR-10 (NORMAL 10.6-15.7).

Date 18th july-sgpt 67 sgot 38.

Date 1st aug-sgpt 66 sgot 37.

after stopping evion then-
Date 14th sept-sgpt 91
bilirubin normal
sgot 36.
only triglycerides elevated to 219.
These are all reports sir.pls kindly revert back sir pls.
also do tell me if if he does proper exercise and diet control will he be prevented from cirrhosis??


doctor
Answered by Dr. Dr.P.Ratnakar Kini (9 hours later)
Brief Answer:
Other investigation reports please

Detailed Answer:
Hi,
I asked for the hepatitis panel and autoimmune work up reports.
Please upload those reports.

Regards,
Dr.R.K.

Brief Answer:
Answer given below

Detailed Answer:
Hi,
I happened to see your review.
So I thought I can explain in detail.

This is an online consultation with limitations.

1. We do not have the option to examine the patient.

2.We do not have the complete medical history or access to the lab reports unless provided by the customer.

We give our opinion based on the information provided by the customer.

===========================================================

In your first post you asked -

1. sir does he need to take evion for life??

2. he was taking 400 units bd.if if he stop taking evion after some months or years den will his sgpt levels increase again despite proper exercise and diet control?

I answered these two questions -
Evion is just a supportive medication. He need not take it lifelong.
Some of the common causes of NAFLD are obesity, diabetes, high cholesterol etc.

Your husband's BMI is 22.7. So he is not obese. ( Obesity/overweight - BMI more than 25). He is also not a diabetic.
The risk factor is high cholesterol . He needs to take medications to bring it under control. Only then his fatty liver will become normal. You can get a prescription from his doctor.

I also gave the advice -
He will get more benefitted if he takes Trimeg.

So all your questions were answered in my first post itself.

==========================================================

In your first follow up question -

You said you FORGOT to mention in your first post that his cholesterol is normal now ( Your first post says cholesterol was elevated).

Then you asked additional questions -

1. Can sgpt be elevated despite normal cholesterol levels also??his hdl cholesterol is 40.

2. Sir do you think fibrosis has set in and that's why sgpt is elevated??

3.and sir is it it definitely XXXXXXX or simple fatty liver.

I answered all these questions -

Within 3-6 months of eliminating the risk factors, the fatty liver will become normal.
To know whether fibrosis has set in a fibroscan may be done.
I presume an ultrasound scan was done to diagnose fatty liver. Simple fatty liver will have normal liver enzymes. Since he is having raised enzymes he is having steatohepatitis.

I also gave additional information -

Whether it is nonalcoholic steatohepatitis (NASH) or steatohepatitis due to other causes can be known only with more tests.

He should be tested for other causes like Hepatitis B and C infections, autoimmune diseases, metabolic diseases of liver.
You can consult a gastroenterologist/hepatologist for these tests.

=========================================================

Then you came up with the second follow up question stating that hepatitis tests were normal and asma ana ttg were also normal.
ceruloplasmin also normal.

YOU DID NOT MENTION ABOUT ALL THESE TESTS IN YOUR FIRST TWO POSTS.

1. then sir what could be reason for elevated sgpt??

2. can you suggest other metabolic tests??

3.sir do you think any other serious reason behind this??


bilirubin was also normal sir.

4.i am under lots of stress sir.pls tell can he have a normal lifespan despite all these problems??

Your first post was only about fatty liver and I answered all those questions.
In your follow up questions you gave information about more tests which you didnt mention in your first post itself and the list was not complete.

But you wanted to know what more should be done.

That is the reason why I asked you to upload all the reports so I can have a look at it and see what is missing.

But even after that you gave information only about

- Liver function test ( which again is incomplete and not showing the alkaline phosphatase and protein values)

- Lipid profile

- Thyroid function test

- Serum amylase and lipase

- ESR

You can see it yourself that the list is incomplete without the following reports -

1. HbsAg
2. Anti HCV
3. Anti LKM1
4. pANCA
5. Anti SLA/LP
6. Alpha1 AT
7. Serum Ferritin

I wanted to know whether these tests were done. That is the reason I asked you to upload the hepatitis panel and autoimmune work up reports.

The ultrasound report was also not mentioned .

It would be easy for me to analyse if the whole report was given instead of asking about tests one by one.
===========================================================

Since you have not uploaded any of these reports and in your earlier post have mentioned hepatitis and autoimmune were normal, I presume all these tests were done.

If even after 6 months of controlling cholesterol he still has steatohepatitis he needs more tests like -

1. HBV DNA
2. HCV RNA
3. Liver biopsy

===========================================================
In your final post you have asked -

if he does proper exercise and diet control will he be prevented from cirrhosis??

The answer -
If the raised enzymes are only due to nonalcoholic fatty liver and he is obese, and all the other risk factors are under control, then exercise and diet control will prevent the disease progression.
But he is not obese. That is the reason I asked you to rule out other causes.

=========================================================

Let me know if you have any more questions.
Regards,
Dr.R.K

Note: For further follow up on digestive issues share your reports here and Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Dr.P.Ratnakar Kini

Gastroenterologist

Practicing since :1994

Answered : 2208 Questions

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Suggest Dosage For Evion

Brief Answer: Treat high cholesterol. Detailed Answer: Hi, Thanks for posting your query. I am Dr.R.K and I am pleased to assist you. Your husband is having non alcoholic fatty liver disease. Some of the common causes of NAFLD are obesity, diabetes, high cholesterol etc. Your husband's BMI is 22.7. So he is not obese. ( Obesity/overweight - BMI more than 25). He is also not a diabetic. The risk factor is high cholesterol . He needs to take medications to bring it under control. Only then his fatty liver will become normal. You can get a prescription from his doctor. Evion is just a supportive medication. He need not take it lifelong. He will get more benefitted if he takes Trimeg. I hope that answers your question. Let me know if you have any more questions. Regards, Dr.R.K