Sign-in to Ask A Doctor - 24x7
OR
Sign in with Google
Suggest Dosage For Sertindole
Question: Hi,
I was until some weeks ago (three weeks) on Sertindole 8 mg, at the beginning with 4 mg and then 8 mg. There was a clear positive effect with Sertindole (Serlect) in the third week (4 mg, 8 mg), but it didn't happened with another 4 mg (12 mg), i mean there was no effect in the third week and effect of 12 mg is very slow. How much should i wait to see the full effect of this new 4 mg (from 8 mg to 12 mg)? I am also intermediate metabolizer for cyp2c19 and cyp2d6
Thanks
I was until some weeks ago (three weeks) on Sertindole 8 mg, at the beginning with 4 mg and then 8 mg. There was a clear positive effect with Sertindole (Serlect) in the third week (4 mg, 8 mg), but it didn't happened with another 4 mg (12 mg), i mean there was no effect in the third week and effect of 12 mg is very slow. How much should i wait to see the full effect of this new 4 mg (from 8 mg to 12 mg)? I am also intermediate metabolizer for cyp2c19 and cyp2d6
Thanks
Brief Answer:
Consultation
Detailed Answer:
Hello, and thanks for your question.
I would wait 8 weeks from the dose increase (8mg to 12mg) to judge for full positive effect. It can sometimes take this long for the receptors in the brain to stabilize and start functioning fully. If you do not see a positive effect after 8 weeks from the last dose increase, I would consider decreasing back to 8mg, as this would avoid side effects of the higher dose while still maintaining the efficacy at 8mg you describe from before.
Please remember to rate and close this answer thread when you are finished and satisfied.
In the future, for continuity of care, I encourage you to contact me directly at my private web address below. After you ask a direct question, it would be my pleasure to be your dedicated personal physician on this website. My name is Dr. Sheppe, and I am an XXXXXXX doctor working in New xxxxxxxxxxxxxxxxxxxxxxxxxxxx, ranked #1 for Psychiatry in the United States (tinyurl.com/psyrank). For a personalized comprehensive evaluation, treatment recommendations, and individual therapy, ask me at HealthCareMagic at this private web address: tinyurl.com/DrSheppeAnswers
Consultation
Detailed Answer:
Hello, and thanks for your question.
I would wait 8 weeks from the dose increase (8mg to 12mg) to judge for full positive effect. It can sometimes take this long for the receptors in the brain to stabilize and start functioning fully. If you do not see a positive effect after 8 weeks from the last dose increase, I would consider decreasing back to 8mg, as this would avoid side effects of the higher dose while still maintaining the efficacy at 8mg you describe from before.
Please remember to rate and close this answer thread when you are finished and satisfied.
In the future, for continuity of care, I encourage you to contact me directly at my private web address below. After you ask a direct question, it would be my pleasure to be your dedicated personal physician on this website. My name is Dr. Sheppe, and I am an XXXXXXX doctor working in New xxxxxxxxxxxxxxxxxxxxxxxxxxxx, ranked #1 for Psychiatry in the United States (tinyurl.com/psyrank). For a personalized comprehensive evaluation, treatment recommendations, and individual therapy, ask me at HealthCareMagic at this private web address: tinyurl.com/DrSheppeAnswers
Above answer was peer-reviewed by :
Dr. Raju A.T
Dear Dr. Sheppe,
Risperdal can be an alternative to go faster in the fight against overactivity of dopaminergic receptors in the brain? Problems with risperdal for weight gain are serious or not?
Thanks, XXXXXXX
Risperdal can be an alternative to go faster in the fight against overactivity of dopaminergic receptors in the brain? Problems with risperdal for weight gain are serious or not?
Thanks, XXXXXXX
Brief Answer:
Followup
Detailed Answer:
Risperdal is more commonly used in the USA compared to sertindole, which is rarely used due to its negative side effects. Risperdal does have weight gain associated with it, approximately 10 pounds on average, but has less likelihood of EPS and dystonic reactions compared to sertindole. It is equal in efficacy to dopamine blockage compared to sertindole.
Please remember to rate and close this answer thread when you are finished and satisfied.
In the future, for continuity of care, I encourage you to contact me directly at my private web address below. After you ask a direct question, it would be my pleasure to be your dedicated personal physician on this website. My name is Dr. Sheppe, and I am an XXXXXXX doctor working in New York City at NewYork-Presbyterian Hospital, ranked #1 for Psychiatry in the United States (tinyurl.com/psyrank). For a personalized comprehensive evaluation, treatment recommendations, and individual therapy, ask me at HealthCareMagic at this private web address: tinyurl.com/DrSheppeAnswers
Followup
Detailed Answer:
Risperdal is more commonly used in the USA compared to sertindole, which is rarely used due to its negative side effects. Risperdal does have weight gain associated with it, approximately 10 pounds on average, but has less likelihood of EPS and dystonic reactions compared to sertindole. It is equal in efficacy to dopamine blockage compared to sertindole.
Please remember to rate and close this answer thread when you are finished and satisfied.
In the future, for continuity of care, I encourage you to contact me directly at my private web address below. After you ask a direct question, it would be my pleasure to be your dedicated personal physician on this website. My name is Dr. Sheppe, and I am an XXXXXXX doctor working in New York City at NewYork-Presbyterian Hospital, ranked #1 for Psychiatry in the United States (tinyurl.com/psyrank). For a personalized comprehensive evaluation, treatment recommendations, and individual therapy, ask me at HealthCareMagic at this private web address: tinyurl.com/DrSheppeAnswers
Note: For further follow up on related General & Family Physician Click here.
Above answer was peer-reviewed by :
Dr. Veerisetty Shyamkumar
Answered by
Get personalised answers from verified doctor in minutes across 80+ specialties
