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Suggest Supplement To Cope Up With Side Effects Of Gabapentin

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Posted on Thu, 24 Apr 2014
Question: Due to new medicaid policy; I am being forced to switch from Lyrica (which I have been on for 8 months) to Gabapentin. I get this (along with cymbalta, hydrocodo/acetaminop, and cyclobenzaprine) from my pain clinic for fibromyalgia. This happened last month too... but after taking one gabapentin I felt like a cloud of confusion rolled over me and I couldn't physically move. I barely got my bi-pap mask on so I could sleep it off. The next day I called in to the nurse to explain my issues and the doc okayed me to go back to lyrica. A new script was called to my pharmacy and I thought that was that. On my next appointment, the doc and I decided to up my dose of lyrica from 200mg day to 300mg day (which is a better pain XXXXXXX dose). I thought things were on the up and up. I even set up my pharmacy account to automatically do my refills that way the pharmacy could contact the clinic early enough for my monthly refills, do all of the prior authorizations ahead of time with Medicaid, and then call me when I could pick up my many monthly scripts. Well, some where in the mix things got messed up. I don't know how, but now there is no record of my first trial with gabapentin... and Medicaid is insisting that I do a two month minimum trial of gabapentin with no chance of getting anymore Lyrica until that trial is over. So I am being forced to try to deal until the middle of May. I don't even have the option of self pay at this point... which I don't understand. My doc is being strong armed by people with no medical degree. I am so frustrated. Anyways, I am scared to take the gabapentin because of what happened last time. I have researched the withdraws of Lyrica to see if I think I can handle it. Well, I can handle all but the risk of vomiting (because I wear a bi-pap mask) and seizures (even though I've never had one). So I feel as if I have no choice but to suck it up and take the gabapentin. My son (age 20) has agreed to play nurse and supervise my meds, food, bi-pap mach/ mask fit, and help me as he can. I bought some depends just in case I can't get to the bathroom in time. So I guess I am as prepared as I can be for the side effects( as I have experienced ). This is the lessor of two evils. It is better than risking a seizure or choking in my sleep. I have expressed my worries and concerns to several doctors, my pharmacy, Medicaid... any one who would listen. However, no one will intervene or let me have a real nurse or admit me into a hospital right now. I have discussed a safety plan with my son so he does know when to call for help or an ambulance if needed. So here is my questions: Is there anything i.e. supplement or over the counter items that I can get to lesson the negative reactions I will have with gabapentin? What is the difference between lyrica and gabapentin as to how it affects brain chemistry? and how they work? Also, should I expect any symptoms of lyrica withdraw even though I will be taking gabapentin?
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Answered by Dr. Vinay Bhardwaj (49 minutes later)
Brief Answer: Tolerating Gabapentin and safety issues. Detailed Answer: Hi! I am so sorry to hear about your troubles with Medicaid. Though I am surprised by this. Even if MEDICAID lost your info. Shouldn't your doctor have the original notes where (s)he prescribed it? Shouldn't the pharmacy that provided the medication have a record? Shouldn't there be a record on your debit card or something when you bought it? My question is. Why can't proof be given to the people at medicaid and your switch BACK to Lyrica be justified? Anyway's.. That's not your question. So let me see to addressing those. 1) There is no known supplement that can help with the side effects of Gabapentin. This is a molecule that is basically tricking the brain into thinking that it is a natural neurotransmitter called GABA. There are not that many other chemicals out there that can even GET INTO your brains circulation let alone interact with GABA or GABApentin. The only advise I have for you is to do EXACTLY what you are doing, take it at night and have someone keep a watchful eye for awhile. The side effects should slowly wear off as your system gets used to the GABApentin. 2) Gabapentin and Pregabalin (Lyrica) are actually pretty similar to each other. They both interact in the brain by tricking the brain into making it think they are natural GABA molecules. GABA is a naturally made neurotransmitter that has a whole host of uses. It's an inhibitory transmitter in general, that means it quiets things down. For some reason your nerves that are causing the fibromyalgia are firing fast and furious and the GABA tricksters are being given to quiet them down. Think of Gabapentin and Pregabalin as Horse whisperers or nerve whisperers. They do have marginally different chemistry. Gabapentin gets broken down in the liver into its inactive form while Pregabalin just gets filtered out by the kidney largely unchanged. If you have liver disease, Gabapentin is the worse choice. Kidney disease, pregabalin is the better choice. This might have some effect in their side effect profile as well since some of the breakdown products that come OUT of the liver after breaking down gabapentin may be causing your side effects. Maintaining good liver health is key! DO NOT USE ALCOHOL ALONG WITH THESE DRUGS!!!! EVER... EVER EVER!!! I can't stress this enough. 3) I'm not expecting too much withdrawal from the stoppage of the Pregabalin since your 'GABA' levels should be well maintained by the Gabapentin that you are starting. That having been said, there is NO way I can forsee all the biochemical consequences of any change in meds. Less so since I do not have your full medical history and I have not examined you. Nontheless. In my experience (I have switched patients the other way, GABApentin to pregabalin) there is little physical consequence to the change. I hesitate to mention this only because I know very little about your history, examination or blood work, but i think it might actually be beneficial. There is another drug that used to be prescribed for Neuropathic pain in the bad old days before the coming of Pregabalin. That drug is actually an antiseizure medication called 'Carbamezipine'. If nothing else is working for you well enough. It may be worth giving that drug a trial. though it's use in pain management has largely been abandoned. I hope I helped. I'm really hoping this Medicaid thing gets sorted out. I wish I had more knowledge of the system, but i'm sitting in India and we don't have that kind of a system here. Anyways. Take care. I do hope things get better for you. Feel free to follow up if i have left you any further questions or new ones arise. Vinay
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Vinay Bhardwaj

Neurologist, Surgical

Practicing since :2006

Answered : 544 Questions

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Suggest Supplement To Cope Up With Side Effects Of Gabapentin

Brief Answer: Tolerating Gabapentin and safety issues. Detailed Answer: Hi! I am so sorry to hear about your troubles with Medicaid. Though I am surprised by this. Even if MEDICAID lost your info. Shouldn't your doctor have the original notes where (s)he prescribed it? Shouldn't the pharmacy that provided the medication have a record? Shouldn't there be a record on your debit card or something when you bought it? My question is. Why can't proof be given to the people at medicaid and your switch BACK to Lyrica be justified? Anyway's.. That's not your question. So let me see to addressing those. 1) There is no known supplement that can help with the side effects of Gabapentin. This is a molecule that is basically tricking the brain into thinking that it is a natural neurotransmitter called GABA. There are not that many other chemicals out there that can even GET INTO your brains circulation let alone interact with GABA or GABApentin. The only advise I have for you is to do EXACTLY what you are doing, take it at night and have someone keep a watchful eye for awhile. The side effects should slowly wear off as your system gets used to the GABApentin. 2) Gabapentin and Pregabalin (Lyrica) are actually pretty similar to each other. They both interact in the brain by tricking the brain into making it think they are natural GABA molecules. GABA is a naturally made neurotransmitter that has a whole host of uses. It's an inhibitory transmitter in general, that means it quiets things down. For some reason your nerves that are causing the fibromyalgia are firing fast and furious and the GABA tricksters are being given to quiet them down. Think of Gabapentin and Pregabalin as Horse whisperers or nerve whisperers. They do have marginally different chemistry. Gabapentin gets broken down in the liver into its inactive form while Pregabalin just gets filtered out by the kidney largely unchanged. If you have liver disease, Gabapentin is the worse choice. Kidney disease, pregabalin is the better choice. This might have some effect in their side effect profile as well since some of the breakdown products that come OUT of the liver after breaking down gabapentin may be causing your side effects. Maintaining good liver health is key! DO NOT USE ALCOHOL ALONG WITH THESE DRUGS!!!! EVER... EVER EVER!!! I can't stress this enough. 3) I'm not expecting too much withdrawal from the stoppage of the Pregabalin since your 'GABA' levels should be well maintained by the Gabapentin that you are starting. That having been said, there is NO way I can forsee all the biochemical consequences of any change in meds. Less so since I do not have your full medical history and I have not examined you. Nontheless. In my experience (I have switched patients the other way, GABApentin to pregabalin) there is little physical consequence to the change. I hesitate to mention this only because I know very little about your history, examination or blood work, but i think it might actually be beneficial. There is another drug that used to be prescribed for Neuropathic pain in the bad old days before the coming of Pregabalin. That drug is actually an antiseizure medication called 'Carbamezipine'. If nothing else is working for you well enough. It may be worth giving that drug a trial. though it's use in pain management has largely been abandoned. I hope I helped. I'm really hoping this Medicaid thing gets sorted out. I wish I had more knowledge of the system, but i'm sitting in India and we don't have that kind of a system here. Anyways. Take care. I do hope things get better for you. Feel free to follow up if i have left you any further questions or new ones arise. Vinay